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Vol. 11, Art. 56 (pp. 688-702)    |    2010       

№ гос. регистрации: 0421000002056

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Erythrocytes in Ebola fever pathogenesis

Dadaeva A.A., Subbotina E.L., Sizikova L.P., Bakulina A.Yu., Malkova E.M.

FSRI SRI of virology and biothechnology “Vector” of the Federal Survice for Survillance on Consumer Rights Protection and Human Well-being
Koltsovo, Novosibirsk region, Russia

Brief summary

Beginning from day 1 post infection of guinea pigs with wild and adapted strains of Ebola virus in hepatocytes of animals the signs of active synthesis were observed as well as the appearence of intracytoplasm oxyfill inclusions. However to day 7 post infection in guinea pigs infected with wild strain of Ebola virus such changes in hepatocytes disappeared in contrast to guinea pigs infected with adapted strain of Ebola virus, where number of hepatocytes with oxyfill inclusions raised significantly and the sedimentation of oxyfill formations on erythrocytes were registered. Besides oxifill inclusions in some hepatocytes the basofill inclusions were met as well as basofill formations on erythrocytes. The presence of such formations on erythrocytes shows the involvment of these cells into migration of proteins during Ebola fever and, consequently, erythrocytes may be the important link of Ebola fever pathogenesis.


Key words

Ebola virus, Ebola fever, pathogenesis, hepatocytes, erythrocytes.

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