SOME MECHANISMS OF BIOENERGY DISORDERS AND OPTIMIZATION OF THE APPROACHES TO ITS PHARMACOTHERAPY
Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency, St. Petersburg, Russia
Kashuro V.A., Dolgo-Saburov V.B., Basharin V.A., Bonitenko E.Yu., Lapina N.V.
The molecular mechanisms of energy supply disorders in the cells during hypoxia are considered. Deficiency of oxidized form NAD and increase NADН/NAD ratio lead to disruptions such as disorders of glycolysis, citric acid cycle, exchange of lipids and amino acids, activation of free-radical processes and apoptosis. The main directions of energy metabolism support therapy during hypoxia are formulated.