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Vol. 11, Art. 34 (pp. 424-431)    |    2010       

№ гос. регистрации: 0421000002034

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Cardio respiratory synchronicity on the background inhibition of renin-angiotensin system by lisinopril

O.G. Kompaniets*, V.M. Pokrovskii*, N.M. Zakharova**

*- Kuban State Medical University,


**- Institute of Cell Biophysics of the RAS

Brief summary

It is known that the phenomenon of synchronization of high frequency of respiratory and cardiac rhythms (SDS) has the vagal nature. Administration of atropine or vagotomy of the initially brought out under the neck skin vagus nerves eliminate synchronization of cardiac rhythms with cardiac patterns in experiments with dogs during thermopolypnea. Our study attempted to determine the role of angiotensin in the implementation of the cardio-respiratory synchronization in men. Key parameters of the SDS were recorded initially in acute pharmacological test while taking converting enzyme inhibitor lisinopril in an initial dose of 5 mg and after a month of the regular intake of this drug by patients with hypertension. It was established that pharmacological blockade of the renin-angiotensin system significantly increases the range of synchronization of respiratory and cardiac rhythms and reduces the duration of synchronization at the minimum boundary of the range. These indicators, as well as the increase in the Kerdo index and decrease Lile - Shtrandera and Zander index suggests an increase of the influence of the parasympathetic section of the autonomic nervous system and increase of the adaptability during drug inhibition of the renin-angiotensin system. Despite the absence of direct chronotropic effect during acute pharmacological trial, as well as during the administration of it for a period of one month, it was suggested of the existence of angiotenzin-depended selective modulation of vagal synchronization of respiratory and cardiac rhythms distinct from the chronotropic effect.


Key words

the synchronization of respiratory and cardiac rhythms, the inhibition of angiotensin-converting enzyme, lisinopril, adaptation, hypertension

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