Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 10, Art. 14 (pp. 198-409)    |    2009       

»

Definition of the technical characteristics and mode selection for the generator low-temperature argon plasma (LTAP). Development of programs for Microbiological and Biomedical TESTS PILOT models to assess sanation and wound healing IMPACT of LTAP

Maevsky E. I., Bogdanova L. A., Selezneva I. I., Davydov G. A., Murashev, A. N., Ermolaeva S. A., Varfolomeev A. F., Yurov D. S., Petrov O. F., Vasiliev M. M., Fortov V. E., Didkovsky N.A., Malashenkova I. K., Vladimirov V. I., D. K. Malashenkov

Brief summary

In the present paper we describe a wide range of preparatory work that had to be performed to establish the technical characteristics and selection of the operating mode of the generator of low-temperature argon plasma (operating at 36-40 ° C). Argon plasma generator is intended for painless sterilization of infected nonhealing wounds and ulcers of different genesis. We have tried to decompose the complex influence of low-temperature plasma into components that can have the most significant effects on biological objects. The paper also highlights research on biological models of different levels of the organization in which was revealed not only the disinfectant but also the healing effects of low-temperature plasma treatment of irradiation on wound. The paper also highlights research on biological models of different levels of the organization in which was revealed not only the disinfectant but also the healing effects of low-temperature plasma treatment on wounds. Programmes and methods of microbiological and biomedical tests are designed. Developed new and reproduced well-known experimental models. These original design used to evaluate the sterilizing, sanifying and wound healing effects of low-temperature argon plasma.


Key words

low-temperature argon plasma; sterilization of infected wounds and ulcers; resistant microorganisms; biological model to test the effect of plasma components in vitro and in vivo.

Reference list

1 L. Bardosh, U.A. Lebedev, Elektrodnii sharovoi SVCh razryad. Fenomenologiya i rezyltati zodnovih izmerenii. // Jyrnal tehnicheskoi fiziki , 1998, t. 68, №12, s. 29-32.


2 Batenin V.M., Klimovskii I.I., Lisov G.V., Troickii V.N. SVCh generatori plazmi: Fizika, tehnika, primenenie. M.: Energoatomizdat, 1988;


3 Benilov M.S., Kosov V.F, Rogov B.V., Sinelshikov V.A. Toki nasisheniya na elektricheskie zondi v potokah himicheski reagiryushei plazmi s raznimi sortami ionov // Tepl. vis. temp.- 1987.- T.25.-№3.-S.573-581.


4 Brune B., Sanday K., fon Kneten A. (1998) Biohimiya, 63, 966-975.


5 Bynatyan K.A Vtorichnaya immynnaya nedostatochnost y hiryrgicheskih bolnih: racionalnaya diagnostika i korrekciya. Avtoreferat na soisk. naychnoi stepeni doktora med.nayk, Moskva, 2007


6 G.V. Byrenko, T.N. Galiga, O.I. Osadchaya, A.M. Boyarskaya Osobennosti immynologicheskoi reaktivnosti y bolnih s varikoznimi troficheskimi yazvami. Hiryrgiya Ykraini №2, 2007 s 107.


7 Byyanov V.M., Rodoman G.N. Problemi profilaktiki nagnoenii posle- operacionnih ran.// Hiryrgiya. – 1996. – № 9. – S. 132-135.


8 Vasileva I.A., Kosov V.F. // Tepl. vis. temp.-1981.-T.19.-№5.-S. 1022.


9 Vladimirov U.A., Archakov A.I. Perekisnoe okislenie lipidov v biologicheskih membranah. 1972, M., Nayka, 172 s.


10 Gazin I. K. Patologiya immyniteta y bolnih saharnim diabetom, oslojnennim gnoino-nekroticheskimi porajeniyami nijnih konechnostei, i korrekciya pri tradicionnom lechenii i ozonoterapii . Immynologiya №1 2008


11 Galeev F.S., Gabdylhakov R.M., Hasanova S.G. Mikrobnii peizaj v razlichnih podrazdeleniyah mnogoprofilnogo gorodskogo stacionara // Klinicheskaya mikrobiologiya i antimikrobnaya himioterapiya.,2000., T.2. – Priloj. №1. – S. 14.


12 V.K. Gostishev «Obshaya hiryrgiya, 2005, Moskva, Geotar Media, 608s.


13 Gostishev V.K., Lipatov K.V., Shehter A.B. i dr. Ispolzovanie NO- soderjashego gazovogo potoka v lechenii gnoinih ran. V Kn. NO-terapiya: teoreticheskie aspekti, klinicheskii opit i problemi primeneniya ekzogennogo oksida azota v medicine. Pod. red. S.V.Gracheva, A.B. Shehtera, N.P.Kozlova, M. 2001. s. 79-82.


14 Grishenko A.A. Razrabotka i obosnovanie harakteristik plazmotrona kosvennogo deistviya dlya obrabotki biotkani: Avtoref. dis. kand. tehn. nayk. M., 1992. 16 s.


15 Gryshko V.I.. Primenenie plazmennogo potoka v kompleksnom lechenii gnoinih ran. avtoref kand. diss. M. 2007. 27 s.


16 S. V. Dambaeva, D. V. Mazyrov, N. M. Golybeva, B. V. Pinegin. Vliyanie nekotorih immynomodylyatorov na fynkcionalnyu aktivnost fagocitarnih kletok perifericheskoi krovi donorov/ Immynologiya. 2000 . N 6. - S. 15-20.


17 Danilina G.A., Chernyha M.U., Alekseeva G.V., Batov A.B., Shaginyan I.A. Formirovanie bioplenok klinicheskimi shtammami bakterii kompleksa Burkholderia cepacia v zavisimosti ot ih fenotipicheskih i genotipicheskih harakteristik. JMEI, 2007, № 1, s3-9


18 V.A. Devyatov i dr.Problemi ambylatornoi gnoinoi hiryrgii i pyti ih resheniya. Chelyabinsk, Pyatigorsk. 2002 g. YDK 617-002.


19 Dmitrenko O.A., Prohorov A.Ya., Matveev S.M., Gincbyrg A.L., Shaginyan I.A. Molekylyarno-geneticheskoe tipirovanie meticillin-rezistentnih shtammov Staphylococcus aureus, videlennih v stacionarah razlichnih regionov Rossii i Belarysi. J.mikrobiol., 2005, №4, s.46-52


20 Dolgyshin I. I., Byharin O. V. Neitrofili i gomeostaz / YrO RAN. – Ekaterinbyrg, 2001. – 279s.


21 Dyvanskii V.A., Eliseenko V.I., Dzagnidze N.S. Vozdyshno-plazmennie potoki v lechenii bolnih s gnoino-nekroticheskimi formami diabeticheskoi stopi, Georgian Medical News, 2003, №3 (96), mart, s.10-12


22 Zyev V.E., Kopitin U.D., Protasevich E.T. Obrazovanie dolgojivyshih plazmodov pri ohlajdenii VCh-razryada potokom vodno-kapelnogo aerozolya//DAN SSSR, 1987, t.296, №2, s.337-340.5]


23 S.A.Ketlinskii, A.S Simbircev. Citokini, S-Pb, Foliant, 2008, 552 s.


24 Kosov V.F., Molotkov V.I., Nefedov A.P. Izmereniya koncentracii zaryajennih chastic v potoke plazmi prodyktov sgoraniya metodom elektricheskogo zonda. // Tepl. vis. tem. -1991. -T. 29. -S. 633.


25 Lipatov K.V., Shehter A.B., Emelyanov A.U. Ispolzovanie oksida azota v setnom lechenii flegmonozno-nekroticheskoi roji. V Kn. NO-terapiya: teoreticheskie aspekti, klinicheskii opit i problemi primeneniya ekzogennogo oksida azota v medicine. Pod. red. S.V.Gracheva, A.B. Shehtera, N.P.Kozlova, M. 2001. s. 82-85.


26 Lipatov K.V., Sopromadze M.A., Shehter A.B., Emelyanov A.U., Grachev S.V. Ispolzovanie gazovogo potoka, soderjashego oksid azota (NO-terapiya) v kompleksnom lechenii gnoinih ran // Hiryrgiya. – 2002. – №2. – s.41-43.


27 Maeda H., Akaike T. (1998) Biohimiya, 63, 1007-1019.


28 Mayanskii A.N. Patogeneticheskie aspekti neitrofilzavisimih reakcii // Patologicheskaya fiziologiya. - 1989. - № 6. - S. 66 - 72.


29 Mayanskii D.N., Mayanskaya S.D. Rol neitrofilov v ishemicheskom i reperfyzionnom povrejdenii miokarda // Terapevt. arh. – 2001. – № 12. – S. 84-88.


30 Maevskii E.I., Aksenova O.G., Bogdanova L.A., Moroz V.V., Senina R.Ya., Pyshkin S.U., Ivanickii G.R. Analiz pobochnih i klinicheskih effektov v hode 1 i 2 fazi klinicheskih issledovanii perftorana// Vestnik slyjbi krovi Rossii,- , 2001, (№4), C.:23-29


31 Menshikova E.V., Zenkov N.K. 1997. Okislitelnii stress pri vospalenii // Yspehi sovrem, biologii. T. 117. R. 155-171.


32 Menshikova E.B., Zenkov N.K. // Yspehi sovrem, biologii. 1997. T. 117. Vip. 2. S. 155.


33 Pasechnik, I. N. Mehanizmi povrejdaushego deistviya aktivirovannih form kisloroda na biologicheskie stryktyri y bolnih v kriticheskih sostoyaniyah / I. N. Pasechnik // Vestnik intensivnoi terapii : Naychno- prakticheskii jyrnal. - 2001. - N 4 . - S. 3-9


34 Petrin S.P., Shehter A.B., Radjabov A.A. i dr. Vliyanie NO-terapii na zajivlenie gnoinih ran. V Kn. NO-terapiya: teoreticheskie aspekti, klinicheskii opit i problemi primeneniya ekzogennogo oksida azota v


medicine. Pod. red. S.V.Gracheva, A.B. Shehtera, N.P.Kozlova, M. 2001. s. 85-88.


35 Pigarevskii V.E. Lizosomalno-kationnii test. Klinicheskaya morfologiya neitrofilnih granylocitov: Sb. naych. tr. Pod red. V.E.Pigarevskogo. L., 1988; s. 87–101.


36 Saprin A. N., Kalinina E. V. Okislitelnii stress i ego rol v mehanizmah apoptoza i razvitiya patologicheskih processov // Ysp. biol. him. -1999. -T. 39. -S. 289-326.


37 Poltanov Evgenii Alekseevich Vliyanie nizkointensivnogo lazernogo izlycheniya na sinteticheskie processi kletok. Avtoreferat na soiskanie ych.stepeni kandidata biol.nayk, 2004


38 Protasevich E.T. Kapichka V., Brablec A. Rezonansnoe ohlajdenie plazmi VCh-razryada parami vodi//JTF, 1985, t.55, №4, s.743-745;


39 Protasevich E.T. Holodnaya neravnovesnaya plazma gazovogo razryada//TVT, 1989, t.27, №6, c.1206-1218


40 Protasevich E.T. Visoko chastotnii razryad vo vlajnom vozdyhe pri davleniyah 1-20 mm rt. st.//«Fizika kosmicheskoi i laboratornoi plazmi», Pod red. A.G. Ponomarenko. COAN, Novosibirsk: Nayka, 1989. s.170—174;


41 Protasevich E.T. VCh-razryad pri ponijennom davlenii v ysloviyah peremennoi vlajnosti vozdyha//Godishnik na vesshite ychebni zavedeniya. «Tehnicheskaya fizika» (Bolgariya), 1990, t.26, №2, s.169-180.;


42 Romanova U.M., Smirnova T.A., Andreev A.L., Ilina T.S., Didenko L.V., Gincbyrg A.L. 2006. Formirovanie bioplenok kak primer socialnogo povedeniya bakterii. Mikrobiologiya. 75: 556-561


43 S.V.Sidorenko, Antibiotikorezistentnost v klinicheskoi praktike. Trydi II - Rossiiskogo nacionalnogo kongressa "Chelovek i lekarstvo", M., 1996. 78-94.


44 Slesarenko A. V. Egorov V.I. Ispolzovanie apparata « Plazon» pri lechenii vospalitelnih zabolevanii naryjnogo i srednego yha Tezisi V Ubileinoi Vsearmeiskoi mejdynarodnoi konferencii "SOVREMENNIE PROBLEMI TERAPII HIRYRGIChESKIH INFEKCII", 2005


45 U.M.Stoiko, E.V.Shaidakov, N.A.Ermakov Kompleksnoe lechenie hronicheskoi venoznoi nedostatochnosti nijnih konechnostei v stadii troficheskih rasstroistv Consilium medicum, Jyrnal dokazatelnoi


medicini dlya praktikyushih vrachei 2001, Tom 3, N 7,.


46 Tarysov B.N., «Pervichnie processi lychevogo porajeniya». M.: Medgiz, 1957


47 R.M.Haitov, B.V. Pinegin, H.I. Istamov «Ekologicheskaya Immynologiya» M., 1995g


48 Himiya plazmi. Pod red. L.S. Polaka i U.A. Lebedeva. Novosibirsk, Nayka, Sibirskoe otd., 1991;


49 Chernyha M.U., Kovtyn V.P, Nikolaeva T.N., Gincbyrg A.L., Shaginyan I.A. Razrabotka modeli persistiryushei infekcii, vizvannoi Pseudomonas aeruginosa i bakteriyami kompleksa Burkholderia cepacia. J.mikrobiol., 2004, № 2, 14-20


50 Chernyha M.U., Shaginyan I.A. Nikolaeva T.N.,Gincbyrg A.L. Vliyanie bakterii kompleksa Burkholderia cepacia i Pseudomonas aeruginosa na kletochnie immynnie reakcii eksperimentalnih jivotnih J.mikrobiol., 2005, № 3, s. 53-57


51 Shaginyan I.A. Bysyek G.P., Aleksandrova G.A. Epidemiologiya i profilaktika gospitalnih infekcii v akysherskih i detskih stacionarah. J. mikrobiol., 2003, № 6, s. 30-36


52 Shaginyan I.A., Dmitrenko O.A. Molekylyarnaya epidemiologiya vnytribolnichnih infekcii, vizivaemih meticillinystoichivimi stafilokokkami. J. mikrobiol. epidemiol.. immynol, 2003, №3, s. 99-109


53 Shaginyan I.A., Dmitrenko O.A. Molekylyarnaya epidemiologiya vnytribolnichnih infekcii, vizivaemih meticillinystoichivimi stafilokokkami. J. mikrobiol. epidemiol.. immynol, 2003, №3, s. 99-109


54 Abercrombie, M., M. H. Flint, and D. W. James. 1956. Wound contraction in relation to collagen formation in scorbutic guinea pigs. J. Embryol. Exp. Morphol. 4:167-175.


55 Yu. Akishev, S. Kroepke, J. Behnisch, A. Hollander, A. Napartovich, N. Trushkin, Proc. Int. Symp. High Pressure Low-Temp. Plasma Chemistry (HAKONE-VII), Greifswald, Germany, 2000, Vol. 2, 481-485


56 Albina J.E., Reichner J.S. (1998) Cancer and Metastasis Reviews, 17, 39-53.


57 Anpilov, E. Barkhudarov, Yu. Bark et al, J. Phys. D: Appl. Phys., 34(2001), 993- 999;


58 Shadyro O., Yurkova I., Kisel M., Brede O. and Arnhold J. Radiation-induced fragmentation of cardiolipin in a model a membrane // Int. J. Radial. Biol. 2004. Vol. 80. R. 239–245.


59 Anpilov, E. Barkhudarov, Yu. Bark et al, J. Phys. D: Appl. Phys., 34(2001), 993- 999


60 Armstrong D.G., Liswood P.J., Todd W.F. 1995. Prevalence of mixed infections in the diabetic pedal wounds. A retrospective review of 112 infections. J. Am. Pediatr. Med. As. 85: 533-537


61 Bal-Price A., Brown G.C. (2000) J. Neurochem., 75, 1455-1464.


62 Bell E, Ivarsson B, Merril C 1979 Production oftissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. PNAS USA 76,1274-1278.


63 Bellows CG, Melcher AH, Aubin JE 1982 Assotiation between tension and orientation of periodontal ligament fibroblasts and exogenous collagen fibers in collagen gels in vitro. J Cell Sci 58, 125-138


64 Billingham, R. E., and P. S. Russell. 1956. Studies on wound healing, with special reference to the phenomenon of contracture in experimental wounds in rabbits skin. Ann. Surg. 144:961-981.


65 Bendy R.H., Nuccio P.A., Wolfe E., Collins B., Tamburro C., Glas W., Martin C.M. 1964. Relationship of quantative wound bacterial counts to healing of decubiti. Effect of topical gentamicin. Antimicrob. Agents Chemother. 4: 147-155


66 Bornside G.H., Bornside B.B. 1979. Comparison between moist swab and tissue biopsy methods for quantification of bacteria in experimentsl incisional wounds. J. Trauma 19: 103-105


67 Bottone E.J., Perez A.A. II. Pseudomonas aeruginosa folliculitis acquired through use of contaminated loofah sponge: an unrecognized potential public health problem// J.clin.microbial.- 1993.-Vol. 31.-P. 480–483.


68 Bowler P.G., Duerden B.I., Armstrong D.G. 2001. Wound microbiology and associated approaches to wound management. Cli. Microbiol. Rev. 14: 244-269


69 Brook I., Frazier E.H. 1990. Aerobic and Anaerobic bacteriology of wounds and citaneous abscesses. Arch. Surg. 125:1445-1451


70 Brook I., Frazier E.H. 1998. Aerobic and anaerobic microbiology of chronic venous ulcers. Int. J. Dermatol. 37:426-428


71 Brook I., Randolph J.G. 1981. Aerobic and Anaerobic bacterial flora of burns in children. J. Trauma. 21:313-318


72 Bult, H. (1996) Mol Mid. Today., 2, 510-518


73 Church D., Elsayed S., Reid O., Winstin B., Lindsay R. 2006. Clin. Micorbiol. Rev. Burn wound infection. 19: 403-434


74 J Clark, R. A. F., J. M. Folkvord, C. E. Hart, M. J. Murray, and J. M. McPherson. 1989. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J. Clin. Invest. 84:1036-1040.


75 Clark RAF (1988). Overview and general considerations of wound repair. In: Clark R.A.F, Henson PM, eds.Molecular and cellular biology of wound repair. New York: Plenum Press: 3-33


76 Clutterbuck AL, Cochrane CA, Dolman J, Percival SL.2007. Evaluating antibiotics for use in medicine using a poloxamer biofilm model. Ann. Clin. Microbiol.15:6:2


77 I. Courtillot, J. Morville, V. Motto-Ros, D. Romanini, Sub-ppb NO2 detection by optical feedback cavity-enhanced absorption spectroscopy with a blue diode laser, Appl. Phys. B 85, 407–412 (2006)